Concepedia

Simultaneous Quantitation of Lidocaine and Its Four Metabolites by High-performance Liquid Chromatography: Application to studies on In Vitro and In Vivo Metabolism of Lidocaine in Rats

Ryosei Kawai, Shoichi Fujita, Tokuji Suzuki

Journal of Pharmaceutical Sciences · 1985 · 43 citations · 29 references

Concepts

MedicinePharmacokineticsPharmacologyDrug MetabolismMass Spectrometric AnalysisNeuropharmacologyAnesthetic Drug PharmacologyAnesthetic PharmacologyDrug DispositionLocal Anesthetic PharmacokineticsMetabolite QuantificationHigh-performance Liquid ChromatographyIn Vivo StudiesIntravenous LidocaineLidocaine PharmacokineticsMetabolite PharmacokineticsPharmacokinetic Parameters

References

29

A Simplex Method for Function Minimization

J. A. Nelder, R. Mead · The Computer Journal · 1965 · 28.9K citations

Natural Sciences, Computer Science, Mathematics +8

The Carbon Monoxide-binding Pigment of Liver Microsomes

Tsuneo Omura, Ryo Sato · Journal of Biological Chemistry · 1964 · 11.8K citations · Full text

Life Sciences, Biochemistry, Chemistry +8

THE TISSUE DISTRIBUTION, METABOLISM AND EXCRETION OF LIDOCAINE IN RATS, GUINEA PIGS, DOGS AND MAN

J.B. Keenaghan, R N Boyes · Journal of Pharmacology and Experimental Therapeutics · 1972 · 203 citations

Pharmacy, Pharmacokinetics, Drug Metabolism +15

THE CONVULSANT POTENCY OF LIDOCAINE AND ITS N-DEALKYLATED METABOLITES

Jeffrey L. Blumer, John M. Strong, Arthur J. Atkinson · Journal of Pharmacology and Experimental Therapeutics · 1973 · 118 citations

Medicine, Pharmacokinetics, Pharmacology +13

THE PHYSIOLOGICAL DISPOSITION OF LIDOCAINE AND ITS COMPARISON IN SOME RESPECTS WITH PROCAINE

Chen-Yü Sung, Aldo P. Truant · Journal of Pharmacology and Experimental Therapeutics · 1954 · 104 citations

Pharmacy, Pharmacokinetics, Pharmacology +11