Identification of novel functional organic anion-transporting polypeptide 1B3 polymorphisms and assessment of substrate specificity - Concepedia

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Identification of novel functional organic anion-transporting polypeptide 1B3 polymorphisms and assessment of substrate specificity

89

Citations

27

References

2011

Year

Ute I. Schwarz, Henriette E. Meyer zu Schwabedissen, Rommel G. Tirona, Atsuko Suzuki, Brenda F. Leake, Younes Mokrab, Kenji Mizuguchi, Richard Ho, Richard B. Kim

Pharmacogenetics and Genomics

Abstract

OATP1B3 polymorphisms that result in altered expression, substrate specificity, and pH-dependent activity may be of potential relevance to hepatic clearance of substrate drugs in vivo.

References

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Polymorphisms in OATP-C Rommel G. Tirona, Brenda F. Leake, Gracia Merino, Journal of Biological Chemistry	2001	617
Drug and Bile Acid Transporters in Rosuvastatin Hepatic Uptake: Function, Expression, and Pharmacogenetics Richard Ho, Rommel G. Tirona, Brenda F. Leake, Gastroenterology Rosuvastatin Hepatic UptakeOxysterolHepatologyBiochemistryBiliary Tract	2006	601
Localization and Genomic Organization of a New Hepatocellular Organic Anion Transporting Polypeptide Jörg König, Yunhai Cui, Anne T. Nies, Journal of Biological Chemistry Slc21a SuperfamilyProtein FunctionGenomic OrganizationSequence HomologyBiochemistry	2000	521
Different Effects of SLCO1B1 Polymorphism on the Pharmacokinetics of Atorvastatin and Rosuvastatin Marja K. Pasanen, Hanna Fredrikson, Pertti J. Neuvonen, Clinical Pharmacology & Therapeutics	2007	428
Polymorphisms in Human Organic Anion-transporting Polypeptide 1A2 (OATP1A2) Wooin Lee, Hartmut Glaeser, Layton H. Smith, Journal of Biological Chemistry Allelic VariantMolecular PhysiologyBiochemistryG Protein-coupled ReceptorDrug Disposition	2005	359
LST-2, A human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers Takaaki Abe, Michiaki Unno, Tohru Onogawa, Gastroenterology OncologyGastrointestinal OncologyOncogenic AgentMedicineLiver Physiology	2001	343
Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel Nicola F. Smith, Milin Acharya, Neil Desai, Cancer Biology & Therapy	2005	236
Human Skeletal Muscle Drug Transporters Determine Local Exposure and Toxicity of Statins Michael J. Knauer, Bradley L. Urquhart, Henriette E. Meyer zu Schwabedissen, Circulation Research	2009	222
Effect of drug transporter genotypes on pravastatin disposition in European- and African-American participants Richard Ho, Leena Choi, Wooin Lee, Pharmacogenetics and Genomics	2007	201

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