Concepedia

Identification of novel functional organic anion-transporting polypeptide 1B3 polymorphisms and assessment of substrate specificity

Ute I. Schwarz, Henriette E. Meyer zu Schwabedissen, Rommel G. Tirona, Atsuko Suzuki, Brenda F. Leake, Younes Mokrab, Kenji Mizuguchi, Richard Ho, Richard B. Kim

Pharmacogenetics and Genomics · 2011 · 89 citations · 27 references

DOI

Abstract

OATP1B3 polymorphisms that result in altered expression, substrate specificity, and pH-dependent activity may be of potential relevance to hepatic clearance of substrate drugs in vivo.

References

27

<i>SLCO1B1</i> Variants and Statin-Induced Myopathy — A Genomewide Study

New England Journal of Medicine · 2008 · 2K citations · Full text

Polymorphisms in OATP-C

Rommel G. Tirona, Brenda F. Leake, Gracia Merino et al. · Journal of Biological Chemistry · 2001 · 617 citations · Full text

Drug and Bile Acid Transporters in Rosuvastatin Hepatic Uptake: Function, Expression, and Pharmacogenetics

Richard Ho, Rommel G. Tirona, Brenda F. Leake et al. · Gastroenterology · 2006 · 601 citations · Full text

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Localization and Genomic Organization of a New Hepatocellular Organic Anion Transporting Polypeptide

Jörg König, Yunhai Cui, Anne T. Nies et al. · Journal of Biological Chemistry · 2000 · 521 citations · Full text

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Different Effects of SLCO1B1 Polymorphism on the Pharmacokinetics of Atorvastatin and Rosuvastatin

Marja K. Pasanen, Hanna Fredrikson, Pertti J. Neuvonen et al. · Clinical Pharmacology & Therapeutics · 2007 · 428 citations