Synthesis and biological evaluation of substituted 4-(OBz)phenylalanine derivatives as novel N-type calcium channel blockers

Selective N-type neuronal voltage-sensitive calcium channel blocker, SNX-111, produces spinal antinociception in rat models of acute, persistent and neuropathic pain.

S. Scott Bowersox, T Gadbois, Tejinder Singh et al. · Journal of Pharmacology and Experimental Therapeutics · 1996 · 276 citations

Medicine, Neuroscience, Pharmacology +17

Mitochondrial dysfunction after experimental and human brain injury and its possible reversal with a selective N-type calcium channel antagonist (SNX-lll)

Bon H. Verweij, Paul Muizelaar, Federico C. Viñas et al. · Neurological Research · 1997 · 150 citations

Life Sciences, Neuroscience, Pharmacology +17

Selective N-Type Calcium Channel Antagonist Omega Conotoxin MVIIA Is Neuroprotective Against Hypoxic Neurodegeneration in Organotypic Hippocampal-Slice Cultures

Ashley K. Pringle, Christopher D. Benham, Lulu Sim et al. · Stroke · 1996 · 95 citations

Medicine, Neuroscience, Pharmacology +17

Selective blockade of N-type voltage-sensitive calcium channels protects against brain injury after transient focal cerebral ischemia in rats

S. Scott Bowersox, Tejinder Singh, Robert R. Luther · Brain Research · 1997 · 47 citations

Life Sciences, Neurobiology, Neuroscience +17

New preparations of the N-methyl-D-aspartate receptor antagonist, 4-(3-phosphonopropyl)-2-piperazinecarboxylic acid (CPP)

Christopher F. Bigge, Sheryl J. Hays, Perry M. Novak et al. · Tetrahedron Letters · 1989 · 29 citations

Medicine, Medicinal Chemistry, Pharmacology +11