Concepedia

Protein binding and hepatic clearance: Studies with tolbutamide, a drug of low intrinsic clearance, in the isolated perfused rat liver preparation

William Schary, Malcolm Rowland

Journal of Pharmacokinetics and Biopharmaceutics · 1983 · 51 citations · 15 references

DOI

Concepts

References

15

A physiological approach to hepatic drug clearance

G. Wilkinson, David G. Shand · Clinical Pharmacology & Therapeutics · 1975 · 1.9K citations

, , +17

Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

K. Sandy Pang, Malcolm Rowland · Journal of Pharmacokinetics and Biopharmaceutics · 1977 · 798 citations

, , +17

Hepatic clearance of drugs. II. Experimental evidence for acceptance of the “well-stirred” model over the “parallel tube” model using lidocaine in the perfused rat liverin situ preparation

K. Sandy Pang, Malcolm Rowland · Journal of Pharmacokinetics and Biopharmaceutics · 1977 · 214 citations

, , +16

Pharmacokinetics of drugs in patients with the nephrotic syndrome.

R Gugler, Don W. Shoeman, David H. Huffman et al. · Journal of Clinical Investigation · 1975 · 141 citations · Full text

, , +17

The Metabolic Fate of Tolbutamide in Man and in the Rat

Richard C. Thomas, George J. Ikeda · Journal of Medicinal Chemistry · 1966 · 134 citations

, , +6