Concepedia

2-Methoxymethylestradiol: a new 2-methoxy estrogen analog that exhibits antiproliferative activity and alters tubulin dynamics

Robert W. Brueggemeier, Abhijit Bhat, Carl J. Lovely, Holly D. Coughenour, Surachai Joomprabutra, Douglas H. Weitzel, Dale D. Vandré, William E. Burak

The Journal of Steroid Biochemistry and Molecular Biology · 2001 · 62 citations · 29 references

DOI

Concepts

References

29

Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death.

M A Jordan, K Wendell, Sheila M. Gardiner et al. · PubMed · 1996 · 783 citations

, , +17

The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth

Theodore Fotsis, Youming Zhang, Michael S. Pepper et al. · Nature · 1994 · 742 citations

, , +12

Distinct populations of microtubules: Tyrosinated and nontyrosinated alpha tubulin are distributed differently in vivo

Gregg G. Gundersen, Michael Kalnoski, J. Chloë Bulinski · Cell · 1984 · 533 citations

, , +5

Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol.

Nancy Klauber, Sareh Parangi, Evelyn Flynn et al. · PubMed · 1997 · 527 citations

, , +15

2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site.

Robert J. D’Amato, C. Michael Lin, Evelyn Flynn et al. · Proceedings of the National Academy of Sciences · 1994 · 409 citations

, , +16