Characterization of a CNS penetrant, selective M₁muscarinic receptor agonist, 77‐LH‐28‐1

Abstract

These data suggest that 77-LH-28-1 is a potent, selective, bioavailable and brain-penetrant agonist at the M1 mAChR and therefore that it represents a better tool than AC-42, with which to study the pharmacology of the M1 mAChR.