Extrinsic protein stabilization by the naturally occurring osmolytes β-hydroxyectoine and betaine

Living with Water Stress: Evolution of Osmolyte Systems

Paul H. Yancey, Mary E. Clark, Steven C. Hand et al. · Science · 1982 · 3.7K citations

Biology, Mechanobiology, Bioorganic Chemistry +15

Mechanism of protein stabilization by glycerol: preferential hydration in glycerol-water mixtures

K. Gekko, Serge N. Timasheff · Biochemistry · 1981 · 1.2K citations

The stabilization of proteins by sucrose.

James Lee, Serge N. Timasheff · Journal of Biological Chemistry · 1981 · 1.1K citations · Full text

Thermal Unfolding, Protein Chemistry, Biochemistry +15

The stabilization of proteins by osmolytes

Tsutomu Arakawa, Serge N. Timasheff · Biophysical Journal · 1985 · 1K citations · Full text

Protein Chemistry, Protein Assembly, Biochemistry +3

Protein stability curves

Wayne J. Becktel, John A. Schellman · Biopolymers · 1987 · 1K citations

Stability Curves, Protein Stability Curves, Free Energy +14