Contribution of mrp2 in alterations of canalicular bile formation by the endothelin antagonist bosentan

Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance-Associated Protein Gene

Coen C. Paulusma, Piter J. Bosma, Guido J.R. Zaman et al. · Science · 1996 · 830 citations

Genetics, Pathology, Molecular Biology +17

Molecular Pathogenesis of Cholestasis

Michael Trauner, Peter J. Meier, James L. Boyer · New England Journal of Medicine · 1998 · 698 citations

Molecular Pathogenesis, Pathology, Cholangiopathies +18

Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist.

Martine Clozel, Volker Breu, Gillian A. Gray et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 667 citations

The Effect of an Endothelin-Receptor Antagonist, Bosentan, on Blood Pressure in Patients with Essential Hypertension

Henry Krum, Reuven J. Viskoper, Yves Lacourcière et al. · New England Journal of Medicine · 1998 · 571 citations · Full text

Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist

Martine Clozel, Volker Breu, Kaspar F. Burri et al. · Nature · 1993 · 529 citations

Medicine, Vascular Pharmacology, Physiology +5