Inactivation of Germline Mutant APC Alleles by Attenuated Somatic Mutations: A Molecular Genetic Mechanism for Attenuated Familial Adenomatous Polyposis

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

Manfred Gossen, Heidelberg Bujard · Proceedings of the National Academy of Sciences · 1992 · 4.9K citations

Viral Replication, Molecular Regulation, Immunology +20

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

Patrice J. Morin, Andrew B. Sparks, Vladimír Kořínek et al. · Science · 1997 · 3.9K citations

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC ^−/− Colon Carcinoma

Vladimír Kořínek, Nick Barker, Patrice J. Morin et al. · Science · 1997 · 3.3K citations

Tcf Reporter Gene, Pathology, Cancer Biology +18

Functional interaction of β-catenin with the transcription factor LEF-1

Jürgen Behrens, Jens Peter von Kries, Michael Kühl et al. · Nature · 1996 · 2.9K citations

Transcriptional Regulation, Signaling Pathway, Molecular Regulation +8

Identification and characterization of the familial adenomatous polyposis coli gene

Joanna Groden, Andrew Thliveris, Wade S. Samowitz et al. · Cell · 1991 · 2.8K citations

Molecular Epidemiology, Genetic Disorder, Medicine +10