Concepedia

Essential Role of the Chaperonin CCT in Rod Outer Segment Biogenesis

Satyabrata Sinha, Marycharmain Belcastro, Poppy Datta, Seongjin Seo, Maxim Sokolov

Investigative Ophthalmology & Visual Science · 2014 · 17 citations · 39 references

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Abstract

Our data provide new evidence indicating the essential role of the chaperonin CCT in the biogenesis of vertebrate photoreceptor sensory cilia, and suggest that it may be due to the direct participation of the chaperonin in the posttranslational processing of selected BBS proteins and assembly of the BBSome.

References

39

A Core Complex of BBS Proteins Cooperates with the GTPase Rab8 to Promote Ciliary Membrane Biogenesis

Maxence V. Nachury, Alexander V. Loktev, Qihong Zhang et al. · Cell · 2007 · 1.4K citations

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Bardet–Biedl syndrome

Elizabeth Forsythe, Philip L. Beales · European Journal of Human Genetics · 2012 · 725 citations · Full text

The Conserved Bardet-Biedl Syndrome Proteins Assemble a Coat that Traffics Membrane Proteins to Cilia

Hua Jin, Susan Roehl White, Toshinobu Shida et al. · Cell · 2010 · 616 citations · Full text

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A cytoplasmic chaperonin that catalyzes β-actin folding

Yijie Gao, J. O. Thomas, Robert L. Chow et al. · Cell · 1992 · 492 citations

Defining the TRiC/CCT interactome links chaperonin function to stabilization of newly made proteins with complex topologies

Alice Yam, Yu Xia, Hen-Tzu Jill Lin et al. · Nature Structural & Molecular Biology · 2008 · 433 citations · Full text

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