Linkage of Chido and HL‐A

Abstract

Of 156 families who were HL‐A typed and Chido‐typed, 15 were found to be suitable for linkage analysis. It was calculated that the odds in favour of linkage of Chido and HL‐A are 1,450,000:1. The maximum likelihood estimate of the Chido : 1.HL‐A recombination fraction is 2½% with 95% confidence limits, obtained graphically, of 0 and 12%; the estimate of the Chido : 2.HL‐A recombination fraction is 1½%, with limits of 0 and 9%. Among Chido negative subjects, the antigens HL‐A12 and W5 occurred more frequently than in a control population.