The Recombination Fraction of the HL‐A System

Abstract

By collecting all the family material available in the seven Danish, Norwegian, and Swedish centres typing for Scandiatransplant, we found 309 families which yielded information on linkage between the first and second segregant series of the HL‐A transplantation system. Information was obtained on 1,362 parental meiotic divisions and recombination has occurred in 11 cases which gives a recombination fraction of 0.0081 with 95% confidence limits of 0.0041–0.0148. The maternal recombination frequency (0.0099) was higher than the paternal one (0.0061), but the difference did not reach statistical significance. Most of the recombinant children belonged to the last half of their sibship.