Concepedia

Combined Therapy of Iron Chelator and Antioxidant Completely Restores Brain Dysfunction Induced by Iron Toxicity

Jirapas Sripetchwandee, Noppamas Pipatpiboon, Nipon Chattipakorn, Siriporn C. Chattipakorn

PLoS ONE · 2014 · 103 citations · 58 references

DOIFull text

Open access

Abstract

In conclusion, this is the first study demonstrating that combined iron chelator and anti-oxidant therapy completely restored brain function impaired by iron overload.

References

58

Morris water maze: procedures for assessing spatial and related forms of learning and memory

Charles V. Vorhees, Michael T. Williams · Nature Protocols · 2006 · 4.5K citations · Full text

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OPEN‐FIELD BEHAVIOR IN THE RAT: WHAT DOES IT MEAN?*

Victor H. Denenberg · Annals of the New York Academy of Sciences · 1969 · 577 citations

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The antioxidants α‐lipoic acid and <i>N</i>‐acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice

Susan A. Farr, H. Fai Poon, Dilek Doğrukol‐Ak et al. · Journal of Neurochemistry · 2003 · 458 citations

Iron regulates nitric oxide synthase activity by controlling nuclear transcription.

Gabriele Werner‐Felmayer, Ernst R. Werner, K Grünewald et al. · The Journal of Experimental Medicine · 1994 · 409 citations · Full text

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Selective iron chelation in Friedreich ataxia: biologic and clinical implications

Nathalie Boddaert, Kim‐Hanh Le Quan Sang, Agnès Rötig et al. · Blood · 2007 · 405 citations