Concepedia

Screening of phosphatidylinositol kinase inhibitors from Streptomyces.

Hiroshi Nishioka, Masaya Imoto, TSUTOMU SAWA, MASA HAMADA, HIROSHI NAGANAWA, TOMIO TAKEUCHI, Kazuo Umezawa

The Journal of Antibiotics · 1989 · 57 citations · 13 references

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Abstract

Recherche d'inhibiteurs de l'enzyme phosphatidylinositol kinase (PIK) parmi les metabolites secondaires de microorganismes. L'acide 2,3-dihydroxybenzoique, isole d'une souche de Streptomyces et l'Orobol, un flavonoide isole d'Aspergillus niger d'une souche de Streptomyces sont des inhibiteurs puissants de la PIK

References

13

Inositol trisphosphate, a novel second messenger in cellular signal transduction

Michael J. Berridge, Robin F. Irvine · Nature · 1984 · 6.1K citations

, , +9

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

Malcolm Whitman, C. Peter Downes, Marilyn L. Keeler et al. · Nature · 1988 · 1K citations

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Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

David R. Kaplan, Malcolm Whitman, Brian Schaffhausen et al. · Cell · 1987 · 669 citations

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<i>Ras</i> -Transformed Cells: Altered Levels of Phosphatidylinositol-4,5-Bisphosphate and Catabolites

Laurie F. Fleischman, Suresh B. Chahwala, Lewis C. Cantley · Science · 1986 · 444 citations

Studies on a new epidermal growth factor-receptor kinase inhibitor, erbstatin, produced by MH435-hF3.

HAMAO UMEZAWA, Masaya Imoto, TSUTOMU SAWA et al. · The Journal of Antibiotics · 1986 · 212 citations · Full text

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