Fumagillin and Fumarranol Interact with P. falciparum Methionine Aminopeptidase 2 and Inhibit Malaria Parasite Growth In Vitro and In Vivo

Human Malaria Parasites in Continuous Culture

William Trager, James B. Jensen · Science · 1976 · 8K citations

Life Sciences, Biology, Infectious Diseases +15

The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2

Ny Sin, Lihao Meng, Margaret Q. W. Wang et al. · Proceedings of the National Academy of Sciences · 1997 · 627 citations

Medicine, Oncology, Pharmacology +13

Structure of Human Methionine Aminopeptidase-2 Complexed with Fumagillin

Shenping Liu, Joanne Widom, Christopher W. Kemp et al. · Science · 1998 · 437 citations

Life Sciences, Biochemistry, Pharmacology +15

Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin

Eric C. Griffith, Zhuang Su, Benjamin E. Turk et al. · Chemistry & Biology · 1997 · 414 citations · Full text

Medicine, Oncology, Pharmacology +9

A three-hybrid system for detecting small ligand–protein receptor interactions

Edward Licitra, Jun O. Liu · Proceedings of the National Academy of Sciences · 1996 · 299 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17