Local inflammation and devascularization — in vivo mechanisms of the “bystander effect” in VPC-mediated HSV-Tk/GCV gene therapy for human malignant glioma

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

Kenneth W. Culver, Zvi Ram, Stuart Wallbridge et al. · Science · 1992 · 1.5K citations

In Vivo Gene Therapy, Neural Stem Cell, Gene Delivery +18

Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection.

Mohammed Adam, A. Dusty Miller · Molecular and Cellular Biology · 1990 · 1.4K citations · Full text

Viral Replication, Xenotransplantation, Stationary Cells +13

The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified.

Sara M. Freeman, Camille N. Abboud, Katharine A. Whartenby et al. · PubMed · 1993 · 1.1K citations

Tumor Regression, Immunology, Viral Pathogenesis +23

Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells

Zvi Ram, Kenneth W. Culver, Eric M. Oshiro et al. · Nature Medicine · 1997 · 682 citations

Neuro-oncology, Medicine, Viral Oncology +6

Curability of Tumors Bearing Herpes Thymidine Kinase Genes Transfered by Retroviral Vectors

F. L. Moolten, John M. Wells · JNCI Journal of the National Cancer Institute · 1990 · 510 citations

Viral Replication, Immunology, Pathology +17