Novel CCK-B receptor agonists: diketopiperazine analogues derived from CCK4 bioactive conformation

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

Michael J. Berridge, R. M. C. Dawson, C. Peter Downes et al. · Biochemical Journal · 1983 · 2K citations · Full text

Life Sciences, Biochemistry, Entomology +14

Evidence for the Neuropeptide Cholecystokinin as an Antagonist of Opiate Analgesia

Patricia L. Faris, Barry R. Komisaruk, Linda R. Watkins et al. · Science · 1983 · 582 citations

Medicine, Neuroscience, Pharmacology +17

Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity.

Joel W. Hughes, P. Boden, B. Costall et al. · Proceedings of the National Academy of Sciences · 1990 · 504 citations

Medicine, Medicinal Chemistry, Pharmacology +13

Enhanced Sensitivity to Cholecystokinin Tetrapeptide in Panic Disorder

Jacques Bradwejn · Archives of General Psychiatry · 1991 · 349 citations

Medicine, Pharmacology, Clinical Pharmacology +8