Loss of The Retinoblastoma Tumor-Suppressor Gene in Parathyroid Carcinoma

Abstract

Inactivation of the RB gene is common in parathyroid carcinoma and is likely to be an important contributor to its molecular pathogenesis. The presence of such inactivation may help to distinguish benign from malignant parathyroid disease and may have useful diagnostic, prognostic, and therapeutic implications.