Potentiation of Apoptosis by Treatment With the Protein Kinase C-Specific Inhibitor Safingol in Mitomycin C-Treated Gastric Cancer Cells - Concepedia

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Potentiation of Apoptosis by Treatment With the Protein Kinase C-Specific Inhibitor Safingol in Mitomycin C-Treated Gastric Cancer Cells

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References

1995

Year

G. K. Schwartz, Adriana Haimovitz‐Friedman, S. K. Dhupar, Desiree Ehleiter, P. Maslak, Lawrence Lai, Frank Loganzo, David P. Kelsen, Zvi Fuks, Anthony P. Albino

JNCI Journal of the National Cancer Institute

Abstract

The PKC inhibitor safingol enhances the cytotoxic effect of the chemotherapeutic agent MMC in gastric cancer cells by promoting drug-induced apoptosis. The induction of apoptosis occurs regardless of the p53 status or the drug-resistance status of the cells.