Concepedia

A Phosphorane as Supported Acylanion Equivalent: Linker Reagents for Smooth and Versatile CC Coupling Reactions

Steffen Weik, Jörg Rademann

Angewandte Chemie International Edition · 2003 · 42 citations · 13 references

DOI

Concepts

Abstract

Smoothly linked: Polymer-supported phosphorane 1 is a C-nucleophile that can be acylated under mild reaction conditions. Diversely substituted α-ketocarbonyl and α-hydroxycarbonyl compounds 2 are furnished following to a reaction sequence including oxidative cleavage of the supported phosphoranes.

References

13

Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generation

Steven V. Ley, Ian R. Baxendale, Robert N. Bream et al. · Journal of the Chemical Society Perkin Transactions 1 · 2000 · 689 citations · Full text

, , +13

Functionalized Polymers-Emerging Versatile Tools for Solution-Phase Chemistry and Automated Parallel Synthesis

Andreas Kirschning, Holger Monenschein, Rüdiger Wittenberg · Angewandte Chemie International Edition · 2001 · 378 citations

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Spectral and chemical properties of dimethyldioxirane as determined by experiment and ab initio calculations

Waldemar Adam, Yuk Yee Chan, Dieter Cremer et al. · The Journal of Organic Chemistry · 1987 · 259 citations

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Synthesis and structure-activity relations of bestatin analogs, inhibitors of aminopeptidase B

RINZO NISHIZAWA, Tetsushi Saino, TOMOHISA TAKITA et al. · Journal of Medicinal Chemistry · 1977 · 163 citations · Full text

, , +10

Oxidizing Polymers: A Polymer-Supported, Recyclable Hypervalent Iodine(V) Reagent for the Efficient Conversion of Alcohols, Carbonyl Compounds, and Unsaturated Carbamates in Solution J.R. gratefully acknowledges generous support from Prof. M. E. Maier, Tübingen, the Strukturfonds of the University of Tübingen, the Fonds der Chemischen Industrie, and the DFG. We thank Graeme Nicholson, Dietmar Schmid, and Daniel Bischoff for analytical support.

Gerhard Sorg, Anne Mengel, Günther Jung et al. · Angewandte Chemie International Edition · 2001 · 140 citations

, , +8