Morphine mediates a proinflammatory phenotype via μ-opioid receptor–PKCɛ–Akt–ERK1/2 signaling pathway in activated microglial cells

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Activated microglia mediate neuronal cell injury via a nitric oxide mechanism

C C Chao, S Hu, Thomas W. Molitor et al. · The Journal of Immunology · 1992 · 1.1K citations

Life Sciences, Neurobiology, Neuroscience +14

A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window

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Life Sciences, Neuroscience, Pharmacology +17

Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia

Juha Yrjänheikki, Riitta Keinänen, M. Pellikka et al. · Proceedings of the National Academy of Sciences · 1998 · 996 citations

Medicine, Pharmacology, Molecular Neurobiology +12

Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta

Sunhee C. Lee, Weiwei Liu, Dennis W. Dickson et al. · The Journal of Immunology · 1993 · 800 citations

Medicine, Neurobiology, Neuroscience +17