A mathematical model of the kinetics of 5-fluorouracil and its metabolites in cancer patients

An Algorithm for Least-Squares Estimation of Nonlinear Parameters

Donald W. Marquardt · Journal of the Society for Industrial and Applied Mathematics · 1963 · 30.4K citations

Natural Sciences, Computational Engineering, Optimization +11

Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile.

Glen D. Heggie, Jean‐Pierre Sommadossi, David S. Cross et al. · PubMed · 1987 · 731 citations

Pharmacy, Clinical Pharmacokinetics, Pharmacology +17

Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity.

Robert B. Diasio, T L Beavers, John T. Carpenter · Journal of Clinical Investigation · 1988 · 500 citations · Full text

Medicine, Biochemistry, Pharmacology +14

Multiexponential, multicompartmental, and noncompartmental modeling. II. Data analysis and statistical considerations

Elliot M. Landaw, Joseph J. DiStefano · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 1984 · 340 citations

Pharmacy, Biostatistics, Pharmacokinetics +16

Nonlinear pharmacokinetic models for 5-fluorouracil in man: Intravenous and intraperitoneal routes

Jerry M. Collins, Robert L. Dedrick, Franklin G. King et al. · Clinical Pharmacology & Therapeutics · 1980 · 179 citations

Pharmacy, Pharmacokinetics, Pharmacology +17