Rapid selection of single cells with high antibody production rates by microwell array

A RAPID METHOD FOR VIABLE CELL TITRATION AND CLONE PRODUCTION WITH HELA CELLS IN TISSUE CULTURE: THE USE OF X-IRRADIATED CELLS TO SUPPLY CONDITIONING FACTORS

Theodore T. Puck, Philip I. Marcus · Proceedings of the National Academy of Sciences · 1955 · 640 citations · Full text

Life Sciences, Evolutionary Biology, Genetics +12

A microengraving method for rapid selection of single cells producing antigen-specific antibodies

J. Christopher Love, Jehnna L. Ronan, Gijsbert M. Grotenbreg et al. · Nature Biotechnology · 2006 · 461 citations

Life Sciences, Biotechnology, Immunology +13

A rapid and efficient single-cell manipulation method for screening antigen-specific antibody–secreting cells from human peripheral blood

Aishun Jin, Tatsuhiko Ozawa, Kazuto Tajiri et al. · Nature Medicine · 2009 · 264 citations

Life Sciences, Cell Biology, Immunology +16

Characterization of chimeric antibody producing CHO cells in the course of dihydrofolate reductase-mediated gene amplification and their stability in the absence of selective pressure

Sang Jick Kim, No Soo Kim, Chun Jeih Ryu et al. · Biotechnology and Bioengineering · 1998 · 221 citations

Pharmacy, Biotechnology, Molecular Biology +17

Intraclonal Protein Expression Heterogeneity in Recombinant CHO Cells

Warren Pilbrough, Trent P. Munro, Peter P. Gray · PLoS ONE · 2009 · 208 citations · Full text

Life Sciences, Biotechnology, Cell Biology +13