Migration of<i>Toxoplasma gondii</i>–Infected Dendritic Cells across Human Retinal Vascular Endothelium

Abstract

Transmigration of human dendritic cells across retinal endothelium is increased following infection with T. gondii. Movement may be impacted by locally produced chemokines and is mediated in part by ICAM-1, VCAM-1, and ALCAM. These findings have implications for development of novel therapeutics aimed at preventing retinal infection by T. gondii.