Identification of Thioredoxin-Interacting Protein 1 as a Hypoxia-Inducible Factor 1α-Induced Gene in Pancreatic Cancer

Abstract

Thioredoxin-interacting protein, a putative tumor suppressor gene, is induced in response to hypoxia in a HIF-1alpha-dependent manner in pancreatic cancer cells, resulting in increased apoptosis and increased sensitivity to platinum anticancer therapy. Increased TXNIP may be a mechanism to counterbalance the prosurvival effects of HIF-1alpha.