Organic Letters · 2005 · 55 citations · 1 references
Life SciencesBiochemistryMedicinal ChemistryMolecular VirologyStructure-activity RelationshipsVirologyAntiviral AgentsAntiviral PharmacologyEnzyme InhibitionMedicinal PlantsNatural Product Drug DiscoveryStructure-activity Relationship AnalysisAntiviral Structure-activity RelationshipsTriterpene BiosynthesisTwo-dimensional Nmr Spectroscopy
[structure: see text]. Two novel triterpene dilactones, kadsuphilactones A (1) and B (2), were isolated from the Taiwanese medicinal plant Kadsura philippinensis. The structures of 1 and 2 were elucidated on the basis of extensive spectroscopic methods, including two-dimensional NMR techniques, and confirmed by X-ray crystallographic analysis. Kadsuphilactone B (2) exhibited in vitro anti-HBV activity with IC(50) values of 6 microg/mL by HBsAg enzyme immunoassay.
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