Polymer-supported reagents for multi-step organic synthesis: application to the synthesis of sildenafil

Sildenafil (VIAGRATM), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction

N.K. Terrett, Andrew Bell, David Brown et al. · Bioorganic & Medicinal Chemistry Letters · 1996 · 606 citations

Medicine, Pharmacology, Pharmacotherapy +12

Functionalised Polymers: Recent Developments and New Applications in Synthetic Organic Chemistry

Stephen J. Shuttleworth, Steven M. Allin, Pradeep K. Sharma · Synthesis · 1997 · 250 citations

Natural Sciences, Chemical Engineering, Chemistry +13

Use of solid supported nucleophiles and electrophiles for the purification of non-peptide small molecule libraries

Stephen W. Kaldor, Miles G. Siegel, James E. Fritz et al. · Tetrahedron Letters · 1996 · 227 citations

Pharmacy, Biochemistry, Medicinal Chemistry +8

The Chemical Development of the Commercial Route to Sildenafil:  A Case History

David J. Dale, Peter J. Dunn, Clare Golightly et al. · Organic Process Research & Development · 1999 · 191 citations

Pharmacy, Chemical Engineering, Medicinal Chemistry +13

Effects of sildenafil on cAMP and cGMP levels in isolated human cavernous and cardiac tissue

Christian G. Stief, Stefan Ückert, Armin Becker et al. · Urology · 2000 · 131 citations

Medicine, Cardiology, Pharmacology +13