Concepedia

Synthesis, SAR study, and biological evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors with reduced CYP3A4 inhibition

Wataru Hamaguchi, Naoyuki Masuda, Satoshi Miyamoto, Yasuhiro Shiina, Shigetoshi Kikuchi, Takuma Mihara, Hiroyuki Moriguchi, Hiroshi Fushiki, Yoshihiro Murakami, Y. Amano,

Bioorganic & Medicinal Chemistry · 2014 · 22 citations · 34 references

DOI

Concepts

References

34

Cloning and Characterization of a Novel Human Phosphodiesterase That Hydrolyzes Both cAMP and cGMP (PDE10A)

Kotomi Fujishige, Jun Kotera, Hideo Michibata et al. · Journal of Biological Chemistry · 1999 · 407 citations · Full text

, , +13

Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A

Scott H. Soderling, Sharon J. Bayuga, Joseph A. Beavo · Proceedings of the National Academy of Sciences · 1999 · 381 citations

, , +13

Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans.

Y. Naritomi, Shigeyuki Terashita, Sumihisa Kimura et al. · PubMed · 2001 · 317 citations

, , +17

Inhibition of the striatum-enriched phosphodiesterase PDE10A: A novel approach to the treatment of psychosis

Judith A. Siuciak, Douglas S. Chapin, John F. Harms et al. · Neuropharmacology · 2006 · 274 citations

, , +12

Phosphodiesterase 10A Inhibitor Activity in Preclinical Models of the Positive, Cognitive, and Negative Symptoms of Schizophrenia

Steven M. Grauer, Virginia Pulito, Rachel L. Navarra et al. · Journal of Pharmacology and Experimental Therapeutics · 2009 · 266 citations

, , +13