Concepedia

Safety and Pharmacokinetics of Lopinavir in HIV/HCV Coinfected Patients with Advanced Liver Disease

José L. Casado, María del Palacio Tamarit, Javier Moya, José M. Rodríguez, Ana Moreno, Maria Jesús Pérez‐Elías, Ana Belso, Fernando Dronda, Santiago Moreno

HIV Clinical Trials · 2011 · 19 citations · 25 references

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Abstract

The risk of lopinavir-associated hepatotoxicity in patients with very advanced liver disease is low. However, lopinavir plasma trough levels are increased, and there is a high interpatient variability.

References

25

Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis†

Robert G. Knodell, Kamal G. Ishak, William C. Black et al. · Hepatology · 1981 · 3.6K citations · Full text

Hepatotoxicity Associated With Antiretroviral Therapy in Adults Infected With Human Immunodeficiency Virus and the Role of Hepatitis C or B Virus Infection

Mark Sulkowski · JAMA · 2000 · 957 citations

Incidence of and Risk Factors for Severe Hepatotoxicity Associated with Antiretroviral Combination Therapy

Ferdinand W N M Wit, Gerrit Jan Weverling, Jan Weel et al. · The Journal of Infectious Diseases · 2002 · 315 citations · Full text

Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples.

F. Peter Guengerich, C G Turvy · Journal of Pharmacology and Experimental Therapeutics · 1990 · 269 citations

Differential alterations of cytochrome P450 proteins in livers from patients with severe chronic liver disease

Jacob George, Michael T. Murray, Karen Byth et al. · Hepatology · 1995 · 228 citations · Full text

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