The Rad23 ubiquitin receptor, the proteasome and functional specificity in transcriptional control

Abstract

The proteasome has been implicated in transcriptional control in a bewildering number of ways, and many questions remain about how functional selectivity is conferred to its action. Here we discuss transcriptional roles for the ubiquitin receptor Rad23 and posit that such receptors may be key players dictating proteasome transcriptional specificity.