Increased soluble interleukin-2 receptor concentration in plasma predicts a decreased cellular response to IL-2

The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.

Richard N. Bamford, Angus Grant, J. D. Burton et al. · Proceedings of the National Academy of Sciences · 1994 · 414 citations

Life Sciences, Cell Biology, Immunology +13

A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.

J. D. Burton, Richard N. Bamford, Christian Peters et al. · Proceedings of the National Academy of Sciences · 1994 · 402 citations

Life Sciences, Immunology, Oncology +12

<i>In vivo</i> administration of purified human interleukin 2. I. Half-life and immunologic effects of the Jurkat cell line-derived interleukin 2.

Michael T. Lotze, L Fráňa, Susan O. Sharrow et al. · The Journal of Immunology · 1985 · 384 citations

Pharmacy, Immunology, Pharmacology +13

Regulation of murine lymphokine production in vivo. III. The lymphoid tissue microenvironment exerts regulatory influences over T helper cell function.

Raymond A. Daynes, Barbara A. Araneo, T Dowell et al. · The Journal of Experimental Medicine · 1990 · 345 citations · Full text

Life Sciences, Cell Biology, Immunology +15

In vivo administration of purified human interleukin-2 to patients with cancer: development of interleukin-2 receptor positive cells and circulating soluble interleukin-2 receptors following interleukin-2 administration.

Michael T. Lotze, Mary Custer, Susan O. Sharrow et al. · PubMed · 1987 · 132 citations

Life Sciences, Immunology, Oncology +12