Concepedia

A Nutrient Sensor Mechanism Controls Drosophila Growth

Julien Colombani, Sophie Raisin, Sophie Pantalacci, Thomas Radimerski, Jacques Montagne, Pierre Léopold

Cell · 2003 · 818 citations · 41 references

DOIFull text

Open access

Concepts

References

41

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Ken Inoki, Yong Li, Tianquan Zhu et al. · Nature Cell Biology · 2002 · 3.1K citations

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mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Do‐Hyung Kim, Dos D. Sarbassov, Siraj M. Ali et al. · Cell · 2002 · 3K citations · Full text

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Ken Inoki, Yong Li, Tian Xu et al. · Genes & Development · 2003 · 1.9K citations · Full text

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Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

Robbie Loewith, Estela Jacinto, Stephan Wullschleger et al. · Molecular Cell · 2002 · 1.9K citations · Full text

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Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

Kenta Hara, Yoshiko Maruki, K. Yoshino et al. · Cell · 2002 · 1.8K citations · Full text

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