1kb of 5′ flanking sequence from mouse MC4R gene is sufficient for tissue specific expression in a transgenic mouse

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

Dennis Huszar, Catherine Lynch, Victoria Fairchild-Huntress et al. · Cell · 1997 · 3K citations · Full text

Medicine, Endocrinology, Neuroscience +11

A short amino acid sequence able to specify nuclear location

Daniel Kalderon, Bruce Roberts, William D. Richardson et al. · Cell · 1984 · 2.6K citations

Life Sciences, Genetics, Molecular Biology +9

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

Michael A. Cowley, James L. Smart, Marcelo Rubinstein et al. · Nature · 2001 · 2.3K citations · Full text

Life Sciences, Neurobiology, Neuroscience +16

Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein

Michael M. Ollmann, Brent D. Wilson, Yingkui Yang et al. · Science · 1997 · 1.9K citations

Life Sciences, Endocrinology, Molecular Biology +14

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.

Kathleen G. Mountjoy, Marty Mortrud, Malcolm J. Low et al. · Molecular Endocrinology · 1994 · 1.1K citations · Full text

Life Sciences, Neurobiology, Neuroscience +17