Science · 1985 · 78 citations · 52 references
Life SciencesGeneticsMolecular GeneticsCellular ImmunologyCytogeneticsImmunogeneticsAntigen Receptor Gene RearrangementGene MappingGenetic MappingT Cell BiologyT Cell DifferentiationT-cell Receptor GeneticsChromosomal RearrangementsT Cell Receptor Beta Chain RearrangementT Cell Receptor RearrangementT-cell Receptor Beta Chain GeneticsT-cell Receptor Gene LociT-cell Receptor Gene OrganizationT-cell Receptor Gene SegmentsT-cell Receptor Locus Rearrangement
The T-cell antigen receptor is a cell-surface molecule that participates in the immune response. In the present experiments the genes encoding the beta chain of the T-cell receptor were found to reside on the long arm of human chromosome 7 at or near band q32. Related sequences were found on the short arm of chromosome 7 in bands p15-21 in some experiments. Chromosomal rearrangements in T-cells from normal individuals and patients with ataxia telangiectasia have previously been observed at and near these map assignments for the beta-chain genes.
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Rebecca Taub, Ilan R. Kirsch, Cynthia C. Morton et al. · Proceedings of the National Academy of Sciences · 1982 · 1.4K citations · Full text
Isolation of cDNA clones encoding T cell-specific membrane-associated proteins
Stephen Μ. Hedrick, David I. Cohen, Ellen A. Nielsen et al. · Nature · 1984 · 1.2K citations