Effects of the combined blockade of EGFR and ErbB-2 on signal transduction and regulation of cell cycle regulatory proteins in breast cancer cells

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

Anne Brunet, Azad Bonni, Michael J. Zigmond et al. · Cell · 1999 · 6.6K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

Andrea C. Carrano, Esther Eytan, Avram Hershko et al. · Nature Cell Biology · 1999 · 1.5K citations

Life Sciences, Cell Biology, Molecular Biology +12

Expression of Epiregulin and Amphiregulin and <i>K-ras</i> Mutation Status Predict Disease Control in Metastatic Colorectal Cancer Patients Treated With Cetuximab

Shirin Khambata‐Ford, Christopher R. Garrett, Neal J. Meropol et al. · Journal of Clinical Oncology · 2007 · 1.1K citations · Full text

Medicine, Genetics, Oncology +17

Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3

Natalia Sergina, Megan Rausch, Donghui Wang et al. · Nature · 2007 · 989 citations · Full text

Medicine, Cancer Biology, Oncology +14

Cyclin E-CDK2 is a regulator of p27Kip1.

Robert J. Sheaff, Mark Groudine, Michael D. Gordon et al. · Genes & Development · 1997 · 927 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17