Design and synthesis of novel bis(l-amino acid) ester prodrugs of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) with improved anti-HBV activity

Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA.

Mary Ann Sells, M L Chen, George Acs · Proceedings of the National Academy of Sciences · 1987 · 1.1K citations · Full text

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Transport of Valganciclovir, a Ganciclovir Prodrug, via Peptide Transporters PEPT1 and PEPT2

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Design, Synthesis, and Characterization of a Series of Cytochrome P₄₅₀3A-Activated Prodrugs (HepDirect Prodrugs) Useful for Targeting Phosph(on)ate-Based Drugs to the Liver^§

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Synthesis and biological evaluation of prodrugs of zidovudine

Sunil Aggarwal, Sudhir R. Gogu, S. R. S. Rangan et al. · Journal of Medicinal Chemistry · 1990 · 128 citations

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Synthesis, <i>in Vitro</i> Antiviral Evaluation, and Stability Studies of Bis(<i>S</i>-acyl-2-thioethyl) Ester Derivatives of 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA) as Potential PMEA Prodrugs with Improved Oral Bioavailability

S. Benzaria, Hélène Pelicano, R. Jeremy Johnson et al. · Journal of Medicinal Chemistry · 1996 · 84 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17