Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

Andrew P. Feinberg, Bert Vogelstein · Nature · 1983 · 2.4K citations

Medicine, Genetics, Molecular Genetics +13

A Second Common Mutation in the Methylenetetrahydrofolate Reductase Gene: An Additional Risk Factor for Neural-Tube Defects?

N.M.J. van der Put, F. Gabreëls, E M Stevens et al. · The American Journal of Human Genetics · 1998 · 1.6K citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Hypomethylation of DNA from Benign and Malignant Human Colon Neoplasms

Susan Goelz, Bert Vogelstein, Stanley R. Hamilton et al. · Science · 1985 · 838 citations

Medicine, Molecular Biology, Oncology +16

Multivitamin Use, Folate, and Colon Cancer in Women in the Nurses' Health Study

Edward L. Giovannucci · Annals of Internal Medicine · 1998 · 767 citations

Agriculture, Nutrition, Nutritional Sciences +15

Folate, Methionine, and Alcohol Intake and Risk of Colorectal Adenoma

Edward L. Giovannucci, Meir J. Stampfer, Graham A. Colditz et al. · JNCI Journal of the National Cancer Institute · 1993 · 711 citations

Medicine, Nutritional Sciences, Oncology +17