Concepedia

A <i>Legionella pneumophila</i> Peptidyl-Prolyl <i>cis</i> - <i>trans</i> Isomerase Present in Culture Supernatants Is Necessary for Optimal Growth at Low Temperatures

Maria A. Söderberg, Nicholas P. Cianciotto

Applied and Environmental Microbiology · 2007 · 40 citations · 37 references

DOI

Concepts

Abstract

Several Legionella pneumophila proteins were highly expressed in low-temperature supernatants. One of these proteins was the peptidyl-prolyl isomerase PpiB. Mutants lacking ppiB exhibited reduced growth at 17 degrees C. Since PpiB lacked a signal sequence and was present in 17 degrees C supernatants of type II and type IV secretion mutants, this protein may be secreted by a novel mechanism.

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