Mercaptide—imidazolium ion‐pair: The reactive nucleophile in papain catalysis

Tissue sulfhydryl groups

George L. Ellman · Archives of Biochemistry and Biophysics · 1959 · 25.9K citations

Biochemistry, Glycobiology, Tissue Physiology +3

An agarose mercurial column for the separation of mercaptopapain and nonmercaptopapain

L.A.Æ. Sluyterman, J. Wijdenes · Biochimica et Biophysica Acta (BBA) - Protein Structure · 1970 · 192 citations

Bioanalysis, Agarose Mercurial Column, Biomolecular Engineering +1

On the Mode of Activation of the Catalytically Essential Sulfhydryl Group of Papain

László Polgár · European Journal of Biochemistry · 1973 · 113 citations · Full text

Ion Pair, Protein Chemistry, Biosynthesis +13

Evidence for histidine in the active site of papain

S. Shaukat Husain, Gordon Lowe · Biochemical Journal · 1968 · 105 citations · Full text

Aldo-keto Reductase, Oligomeric Species, Biochemistry +10

Acyl-transfer reactions of amides and esters with alcohols and thiols. Reference system for the serine and cysteine proteinases. Nitrogen protonation of amides and amide-imidate equilibriums

Alan R. Fersht · Journal of the American Chemical Society · 1971 · 90 citations

Engineering, Biochemistry, Nitrogen Protonation +9