Adaptive Optimal Design for Bridging Studies with an Application to Population Pharmacokinetic Studies

Continual Reassessment Method: A Practical Design for Phase 1 Clinical Trials in Cancer

John O’Quigley, Margaret S. Pepe, Lloyd D. Fisher · Biometrics · 1990 · 1.6K citations

Cancer Management, Clinical Endpoint, Dose Toxicity Curve +17

Implementation of a transit compartment model for describing drug absorption in pharmacokinetic studies

Radojka M. Savić, Daniël M. Jonker, Thomas Kerbusch et al. · Journal of Pharmacokinetics and Pharmacodynamics · 2007 · 487 citations

Pharmacokinetic Studies, Pharmacokinetic Modeling, Pharmacological Study +8

Innovative Approaches for Designing and Analyzing Adaptive Dose-Ranging Trials

Björn Bornkamp, Frank Bretz, Alex Dmitrienko et al. · Journal of Biopharmaceutical Statistics · 2007 · 193 citations

Pharmacotherapy, Inadequate Selection, Adaptive Dose-ranging Methods +17

Development and implementation of the population Fisher information matrix for the evaluation of population pharmacokinetic designs

Sylvie Retout, Stephen B. Duffull, France Mentré · Computer Methods and Programs in Biomedicine · 2001 · 133 citations

Pharmacokinetic Modeling, Biostatistics, Pharmacogenomics +7

Incorporating prior parameter uncertainty in the design of sampling schedules for pharmacokinetic parameter estimation experiments

David Z. D’Argenio · Mathematical Biosciences · 1990 · 82 citations

Pharmacokinetic Modeling, Uncertainty Quantification, Medicine +8