Epigenetic alterations in neuroendocrine tumors: methylation of RAS-association domain family 1, isoform A and p16 genes are associated with metastasis

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

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Specific Inhibition, Transcriptional Regulation, Signal Transduction +14

A 5‐decade analysis of 13,715 carcinoid tumors

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CpG island methylator phenotype in colorectal cancer

Minoru Toyota, Nita Ahuja, Mutsumi Ohe-Toyota et al. · Proceedings of the National Academy of Sciences · 1999 · 2.5K citations

Tumor Biology, Aberrant Methylation, Medicine +12

A gene hypermethylation profile of human cancer.

Manel Esteller, Paul G. Corn, Stephen B. Baylin et al. · PubMed · 2001 · 2K citations

Cancer Research, Chromatin, Epigenetic Change +14

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

Adrian Merlo, James G. Herman, Li Mao et al. · Nature Medicine · 1995 · 2K citations

Tumor Biology, Transcriptional Regulation, Medicine +14