Hydrogen peroxide induces apoptosis of chondrocytes; involvement of calcium ion and extracellular signal-regulated protein kinase

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

Donald W. Nicholson, Ambereen Ali, Nancy A. Thornberry et al. · Nature · 1995 · 4K citations

Protein Function, Biochemistry, Ice/ced-3 Protease +11

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

David T. Dudley, Long Pang, Stuart J. Decker et al. · Proceedings of the National Academy of Sciences · 1995 · 2.7K citations · Full text

Signal Transduction, Pd 098059, Cell Regulation +14

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

Keisuke Kuida, Timothy S. Zheng, Songqing Na et al. · Nature · 1996 · 1.9K citations

Molecular Neuroscience, Apoptosis, Autophagy +12

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

Long Pang, Takeshi Sawada, Stuart J. Decker et al. · Journal of Biological Chemistry · 1995 · 904 citations · Full text

Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats.

Ryuichi Aikawa, Issei Komuro, Tsutomu Yamazaki et al. · Journal of Clinical Investigation · 1997 · 688 citations · Full text

Cardiac Muscle, Extracellular Signal-regulated Kinases, Cell Death +17