Coexpression of B7-1 and viral (“self”) transgenes in pancreatic β cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

Vijay K. Kuchroo, Mercy Prabhu Das, Julia A. Brown et al. · Cell · 1995 · 1.7K citations · Full text

Life Sciences, Immunology, Molecular Biology +15

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

Fiona Harding, James G. McArthur, Jane A. Gross et al. · Nature · 1992 · 1.6K citations

Life Sciences, Cell Biology, Immunology +14

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

Pamela S. Ohashi, Stephan Oehen, Kurt Buerki et al. · Cell · 1991 · 1.2K citations

Life Sciences, Immunology, Molecular Biology +15

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

Michael B. A. Oldstone, Michael Nerenberg, Peter J. Southern et al. · Cell · 1991 · 755 citations

Life Sciences, Endocrinology, Immunology +14

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.

Deborah J. Lenschow, Shu‐Chuan Ho, Husain Sattar et al. · The Journal of Experimental Medicine · 1995 · 587 citations · Full text

Life Sciences, Endocrinology, Immunology +17