Concepedia

Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype

Linda Holmquist Mengelbier, Erik Fredlund, Tobias Löfstedt, Rosa Noguera, Samuel Navarro, Helén Nilsson, Alexander Pietras, Johan Vallon‐Christersson, Åke Borg, Katarina Gradin,

Cancer Cell · 2006 · 723 citations · 50 references

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References

50

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

Andrew Epstein, Jonathan Gleadle, Luke A. McNeill et al. · Cell · 2001 · 3.3K citations · Full text

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Cellular and developmental control of O<sub>2</sub> homeostasis by hypoxia-inducible factor 1α

Narayan V. Iyer, Lori E. Kotch, Faton Agani et al. · Genes & Development · 1998 · 2.5K citations · Full text

, , +16

Regulation of hypoxia-inducible factor 1α is mediated by an O <sub>2</sub> -dependent degradation domain via the ubiquitin-proteasome pathway

Eric Huang, Jie Gu, Maureen Schau et al. · Proceedings of the National Academy of Sciences · 1998 · 2.1K citations · Full text

, , +15

HIF‐1α is required for solid tumor formation and embryonic vascularization

Heather E. Ryan · The EMBO Journal · 1998 · 1.6K citations · Full text

, , +14

Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

David Lando, Daniel J. Peet, Dean A. Whelan et al. · Science · 2002 · 1.5K citations

, , +14