Instability of mutant Cu/Zn superoxide dismutase (Ala4Thr) associated with familial amyotrophic lateral sclerosis

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

D.R. Rosen, Teepu Siddique, David T. Patterson et al. · Nature · 1993 · 7K citations

Life Sciences, Genetics, Neuroscience +14

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

Mark E. Gurney, Haifeng Pu, Arlene Y. Chiu et al. · Science · 1994 · 4.1K citations

Life Sciences, Genetics, Neuroscience +17

Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis.

M E Ripps, George W. Huntley, Patrick R. Hof et al. · Proceedings of the National Academy of Sciences · 1995 · 712 citations

Life Sciences, Genetics, Neuroscience +17

Superoxide Dismutase Activity, Oxidative Damage, and Mitochondrial Energy Metabolism in Familial and Sporadic Amyotrophic Lateral Sclerosis

Allen C. Bowling, Jörg B. Schulz, Robert H. Brown et al. · Journal of Neurochemistry · 1993 · 632 citations

Life Sciences, Neurology, Neuroscience +17

Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity.

David Borchelt, Michael K. Lee, Hilda S. Slunt et al. · Proceedings of the National Academy of Sciences · 1994 · 628 citations

Life Sciences, Biochemistry, Molecular Biology +17