Low CTLA-4 expression in CD4+ helper T-cells in patients with fulminant type 1 diabetes

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

Craig L. Bennett, Jacinda R. Christie, Fred Ramsdell et al. · Nature Genetics · 2001 · 3.3K citations

Autoimmune Disease, Disease Mechanism, Genetic Disorder +12

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

Elizabeth Tivol, Frank Borriello, Alain Schweitzer et al. · Immunity · 1995 · 2.9K citations · Full text

Lymphoid Neoplasia, Autoimmune Disease, Immunology +6

CTLA-4 Control over Foxp3 ⁺ Regulatory T Cell Function

Kajsa Wing, Yasushi Onishi, Paz Prieto-Martin et al. · Science · 2008 · 2.8K citations

T-regulatory Cell, Immunology, Immune Regulation +20

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

Mary E. Brunkow, Eric W. Jeffery, Kathryn A. Hjerrild et al. · Nature Genetics · 2001 · 2.6K citations

New Forkhead/winged-helix Protein, Immunology, Pathology +6

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

Hironori Ueda, Joanna M. M. Howson, Laura Esposito et al. · Nature · 2003 · 2.2K citations · Full text

Immunogenetics, Autoimmune Disease, T-regulatory Cell +9