Concepedia

Next-Generation Sequencing Reveals a Novel NSCLC ALK F1174V Mutation and Confirms ALK G1202R Mutation Confers High-Level Resistance to Alectinib (CH5424802/RO5424802) in ALK-Rearranged NSCLC Patients Who Progressed on Crizotinib

Sai‐Hong Ignatius Ou, Michele C. Azada, David Hsiang, June Herman, Tatiana S. Kain, Christina T. Siwak-Tapp, Cameron Casey, Jie He, Siraj M. Ali, Samuel J. Klempner,

Journal of Thoracic Oncology · 2014 · 168 citations · 14 references

DOIFull text

Open access

References

14

New Guidelines to Evaluate the Response to Treatment in Solid Tumors

Patrick Therasse, Susan G. Arbuck, Elizabeth A. Eisenhauer et al. · JNCI Journal of the National Cancer Institute · 2000 · 15.7K citations

, , +17

Mechanisms of Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancers

Ryohei Katayama, Alice T. Shaw, Tahsin Khan et al. · Science Translational Medicine · 2012 · 1.3K citations

EML4-ALK Mutations in Lung Cancer That Confer Resistance to ALK Inhibitors

Young Lim Choi, Manabu Soda, Yoshihiro Yamashita et al. · New England Journal of Medicine · 2010 · 1.2K citations · Full text

, , +16

Mechanisms of Resistance to Crizotinib in Patients with <i>ALK</i> Gene Rearranged Non–Small Cell Lung Cancer

Robert C. Doebele, Amanda Pilling, Dara L. Aisner et al. · Clinical Cancer Research · 2012 · 1.1K citations · Full text

Oncogenic mutations of ALK kinase in neuroblastoma

Yuyan Chen, Junko Takita, Young Lim Choi et al. · Nature · 2008 · 906 citations

, , +4