A method of computing drug distribution in plasma using stepwise association constants: Clofibrate acid as an illustrative example

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

George Scatchard · Annals of the New York Academy of Sciences · 1949 · 19.9K citations

Protein Chemistry, Protein Function, Protein Assembly +5

A physiological approach to hepatic drug clearance

G. Wilkinson, David G. Shand · Clinical Pharmacology & Therapeutics · 1975 · 1.9K citations

A graphic method for the determination and presentation of binding parameters in a complex system

Hannah Rosenthal · Analytical Biochemistry · 1967 · 1.5K citations

Engineering, Chemical Analysis, Graphic Method +9

Analysis of macromolecule-ligand binding by determination of stepwise equilibrium constants

John Fletcher, Arthur A. Spector, J. Douglas Ashbrook · Biochemistry · 1970 · 159 citations

Engineering, Chemical Analysis, Altmetric Attention Score +26

Protein interactions with small molecules. Relationships between stoichiometric binding constants, site binding constants, and empirical binding parameters.

IM Klotz, D. L. Hunston · Journal of Biological Chemistry · 1975 · 152 citations · Full text

Chemical Analysis, Molecular Biology, Computational Chemistry +16