Concepedia

Acceleration of Gastric Tumorigenesis Through MKRN1-Mediated Posttranslational Regulation of p14ARF

Aram Ko, Ji-Young Shin, Jinho Seo, Kang-Duck Lee, Eun‐Woo Lee, Min-Sik Lee, Han‐Woong Lee, Il Ju Choi, Jin Sook Jeong, Kyung‐Hee Chun,

JNCI Journal of the National Cancer Institute · 2012 · 75 citations · 34 references

DOIFull text

Open access

Abstract

We demonstrated that MKRN1 functions as a novel E3 ligase of p14ARF and that it potentially regulates cellular senescence and tumorigenesis in gastric cancer.

References

34

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

Yanping Zhang, Yue Xiong, Wendell G. Yarbrough · Cell · 1998 · 1.6K citations · Full text

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Role of the INK4a Locus in Tumor Suppression and Cell Mortality

Manuel Serrano, Han‐Woong Lee, Lynda Chin et al. · Cell · 1996 · 1.6K citations · Full text

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Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

Takehiko Kamijo, Frédérique Zindy, Martine F. Roussel et al. · Cell · 1997 · 1.6K citations · Full text

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

Dawn E. Ouelle, Frédérique Zindy, Richard A. Ashmun et al. · Cell · 1995 · 1.5K citations · Full text

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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

Frédérique Zindy, Christine M. Eischen, David H. Randle et al. · Genes & Development · 1998 · 1.2K citations · Full text