The <i>N</i>-Hydroxymethyl Group for Stereoselective Conjugate Addition:  Application to the Synthesis of (−)-Statine

Abstract

[reaction: see text] Efficient synthesis of enantiomerically pure (-)-statine was achieved with the stereoselective intramolecular conjugate addition of the hydroxyl group tethered to the amino group of a configurationally stable N-Boc-L-leucinal derivative.